Beilstein J. Org. Chem.2012,8, 1400–1405, doi:10.3762/bjoc.8.162
can be controlled by using peroxide-free aprotic solvents at lower temperature.
Conclusion
We have demonstrated the synthesis and complete characterization of some of the critical impurities of eletriptan hydrobromide (1). This investigation helped us to establish the impurityprofile of 1.
Related
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Graphical Abstract
Figure 1:
Related compounds of eletriptan hydrobromide.
Beilstein J. Org. Chem.2011,7, 29–33, doi:10.3762/bjoc.7.5
.
Keywords: impurityprofile; related substances; sertindole; Introduction
The safety of a drug product is not only dependent on the toxicological properties of the active drug substance (or API), but also on the impurities formed during the various chemical transformations. Therefore, identification
difficult for the organic chemist who must then design a synthesis, which is time consuming. The development of a drug substance is incomplete without the identification of an impurityprofile involved in the process. Furthermore, it is not mandatory to design synthetic routes for the impurities. Thus, in
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Graphical Abstract
Figure 1:
Sertindole (1), process related impurities and metabolites.